GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Patients with PNES had higher self-reported anxiety and depression levels (GAD-7: p = 0.04, PHQ-9: p < 0.01; BDI-II: p < 0.01) but similar QOL to PWE (p = 0.78). 31759316 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 AlteredExpression disease BEFREE Patients with PNES had higher self-reported anxiety and depression levels (GAD-7: p = 0.04, PHQ-9: p < 0.01; BDI-II: p < 0.01) but similar QOL to PWE (p = 0.78). 31759316 2020
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.300 Biomarker group BEFREE We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort. 31713011 2020
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 AlteredExpression disease BEFREE Patients with PNES had higher self-reported anxiety and depression levels (GAD-7: p = 0.04, PHQ-9: p < 0.01; BDI-II: p < 0.01) but similar QOL to PWE (p = 0.78). 31759316 2020
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE Our study offers preliminary evidence for use of the PSWQ-A and GAD-7 for assessment of anxiety in a sample of low-income, predominantly African American participants. 30810345 2020
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 AlteredExpression disease BEFREE To assess the levels of depression and anxiety, the PHQ-9 (The Patient Health Questionnaire), GAD-7 (Generalized Anxiety Disorder), SHS (Subjective Happiness Scale), and IPIP Big-5 questionnaires were used. 31117829 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.100 AlteredExpression group BEFREE Patients with PNES had higher self-reported anxiety and depression levels (GAD-7: p = 0.04, PHQ-9: p < 0.01; BDI-II: p < 0.01) but similar QOL to PWE (p = 0.78). 31759316 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.100 Biomarker group BEFREE Our study offers preliminary evidence for use of the PSWQ-A and GAD-7 for assessment of anxiety in a sample of low-income, predominantly African American participants. 30810345 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.100 AlteredExpression group BEFREE To assess the levels of depression and anxiety, the PHQ-9 (The Patient Health Questionnaire), GAD-7 (Generalized Anxiety Disorder), SHS (Subjective Happiness Scale), and IPIP Big-5 questionnaires were used. 31117829 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.100 GeneticVariation group BEFREE Post hoc analyses in 712 smokers with AD (posttraumatic stress disorder [PTSD], n = 192; generalized anxiety disorder [GAD], n = 243; panic disorder [PD], n = 277) and in a nonpsychiatric cohort (NPC; n = 4,028). 31850603 2020
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort. 31713011 2020
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort. 31713011 2020
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease BEFREE Cells expressing atlastin-1 coexpressed the inhibitory synaptic marker GAD67 in the temporal cortex and hippocampus of patients with epilepsy and an epileptic mouse model. 31729196 2020
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 GeneticVariation disease BEFREE In this prospective observational study, 200 patients admitted to two level 4 EMUs completed standardized surveys including the Quality of Life in Epilepsy (QOLIE-31-P), Generalized Anxiety Disorder 7-item (GAD-7), Patient Health Questionnaire (PHQ-9), and Beck Depression Inventory-II (BDI-II). 31759316 2020
CUI: C0270549
Disease: Generalized Anxiety Disorder
Generalized Anxiety Disorder
0.100 Biomarker disease BEFREE We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort. 31713011 2020
CUI: C0270549
Disease: Generalized Anxiety Disorder
Generalized Anxiety Disorder
0.100 GeneticVariation disease BEFREE African American and Caucasian participants from three community-based clinical trials testing treatments for late-life worry/anxiety were pooled to examine the factor structure, internal consistency reliability, and convergent, discriminant, and predictive validity of the Penn State Worry Questionnaire-Abbreviated (PSWQ-A), Generalized Anxiety Disorder-7 (GAD-7) and Geriatric Anxiety Inventory-short form (GAI-SF). 30810345 2020
CUI: C0270549
Disease: Generalized Anxiety Disorder
Generalized Anxiety Disorder
0.100 GeneticVariation disease BEFREE This was a cross-sectional study.The Aggression Questionnaire (AQ-K), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), the Patient Health Questionnaire-9 (PHQ-9), and the Generalized Anxiety Disorder-7 (GAD-7) were utilized in the study. 31835057 2020
CUI: C0270549
Disease: Generalized Anxiety Disorder
Generalized Anxiety Disorder
0.100 GeneticVariation disease BEFREE In this prospective observational study, 200 patients admitted to two level 4 EMUs completed standardized surveys including the Quality of Life in Epilepsy (QOLIE-31-P), Generalized Anxiety Disorder 7-item (GAD-7), Patient Health Questionnaire (PHQ-9), and Beck Depression Inventory-II (BDI-II). 31759316 2020
CUI: C0270549
Disease: Generalized Anxiety Disorder
Generalized Anxiety Disorder
0.100 GeneticVariation disease BEFREE To assess the levels of depression and anxiety, the PHQ-9 (The Patient Health Questionnaire), GAD-7 (Generalized Anxiety Disorder), SHS (Subjective Happiness Scale), and IPIP Big-5 questionnaires were used. 31117829 2020
CUI: C0270549
Disease: Generalized Anxiety Disorder
Generalized Anxiety Disorder
0.100 GeneticVariation disease BEFREE To address this gap, this study used data from the Intern Health Study, which follows students from the end of medical school through the first year of residency, recording depression via the 9-item Patient Health Questionnaire (PHQ-9), anxiety via the 7-item Generalized Anxiety Disorder Questionnaire (GAD-7), and multiple risk factors for these symptoms. 31084447 2020
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.100 AlteredExpression phenotype BEFREE Patients with PNES had higher self-reported anxiety and depression levels (GAD-7: p = 0.04, PHQ-9: p < 0.01; BDI-II: p < 0.01) but similar QOL to PWE (p = 0.78). 31759316 2020
Attention deficit hyperactivity disorder
0.020 AlteredExpression disease BEFREE Methylation of the GAD1/GAD67 gene, which encodes the key glutamate-to-GABA-synthesising enzyme glutamate decarboxylase 1, resulting in increased levels of glutamate, is one epigenetic mechanism that may account for a tendency towards excitation in disorders such as ADHD. 31758712 2020
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Primary outcome measures were assessed with the Generalized Anxiety Disorder Scale (GAD-7), Personal Health Questionnaire Depression Scale (PHQ-8), Perceived Stress Scale (PSS-14), and Pittsburgh Sleep Symptom Questionnaire-Insomnia (PSSQ-1). 29351138 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Changes in DEMS correlated with changes in both PHQ-8 and GAD-7 in the subgroup of patients without prior depression or anxiety diagnosis (ρ = 0.6, P = 0.002; ρ = 0.4, P = 0.02). 30950896 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Of the 336 usable responses, 16.1% scored 10 or greater on the PHQ-8 consistent with current depression while 17.3% scored 10 or greater on the GAD-7 consistent with current anxiety. 30637564 2019